Ua kev zoo siab rau RADOBIO Incubator Shaker rau kev pab CAS pab pawg tshawb fawb luam tawm hauv Nature thiab Science

Lub Plaub Hlis 3, 2024,YiXiao Zhang's Labnyob rau ntawm Center for Intersection of Biology and Chemistry, Shanghai Institute of Organic Chemistry, Suav Academy of Sciences (SIOC), koom tes nrogCharles Cox's Labntawm Vitor Chang Heart Institute, Australia, thiabBen Corry's Labntawm Australian National University (ANU), luam tawm ib tsab xov xwm hauvXwmhu ua Mechanical activation opens lipid-lined pore hauv OSCA ion channels. Los ntawm kev sib sau OSCA cov proteins rau hauv nanophospholipid disks thiab liposomes los simulate cov neeg kho tshuab ib puag ncig, peb-dimensional conformation ntawm kev ua kom lub xeev ntawm OSCA proteins raug ntes, lub molecular mechanism ntawm lawv cov neeg kho tshuab activation tau elucidated, thiab ib tug tshiab daim ntawv ntawm ion pore muaj pes tsawg leeg nrog phospholipid kev npaj tau pom.

Tsab ntawv hais tias aHerocell C1 CO2 incubator shakertsim los ntawmRADOBIOtau siv rau hauv kev sim.

Txuas mus rau thawj tsab xov xwm: https://www.nature.com/articles/s41586-024-07256-9

Rov qab rau Lub Yim Hli 18, 2023,Charles Cox's Labntawm Victor Chang Heart Institute hauv Australia thiabYiXiao Zhang's LabNyob rau ntawm Lub Chaw rau Kev Siv Tshuaj lom neeg thiab tshuaj lom neeg ntawm Shanghai Institute of Organic Chemistry, Suav Academy of Sciences (SIOC), tau tshaj tawm ib tsab xov xwm hauvKev tshawb fawbmuaj cai MyoD-tsev neeg inhibitor proteins ua haujlwm pab pawg ntawm Piezo channels. subunits ntawm Piezo channels. Tsab ntawv xov xwm tseem hais txog tias Herocell C1 txhua lub hom phiaj carbon dioxide incubator tsim los ntawm Rundle Biologicals tau siv hauv lawv qhov kev sim. (Yog xav paub ntxiv, saib BioArt: Science 丨Charles Cox / Zhang Xiaoyi pab pawg pom MDFIC yog Piezo auxiliary subunit koom nrog hauv kev tswj hwm kev tswj hwm)

Original link: https://www.science.org/doi/10.1126/science.adh8190

 
Pab kev tshawb fawb txog kev tshawb fawb, thev naus laus zis kom paub txog kev zoo nkauj ntawm lub neej. Nws yeej ib txwm ua lub luag haujlwm ntawm Radobio. Niaj hnub no, peb zoo siab dua rau txoj haujlwm no! Raws li lub hnub qub khoom ntawm Radobio, Herocell C1 CO2 Incubator Shaker tau muab kev txhawb zog rau cov kws tshawb fawb nrog nws cov kev ua tau zoo thiab kev ua haujlwm ruaj khov. Peb zoo siab heev uas muaj peev xwm pab YiXiao Zhang 's Lab ua qhov tseem ceeb hauv lawv txoj kev tshawb fawb.

Kev zoo nkauj ntawm thev naus laus zis nyob hauv nws lub peev xwm los coj lub neej zoo dua thiab kev noj qab haus huv rau tib neeg. Qhov kev tshawb pom los ntawm Zhang's Lab yog qhov piv txwv zoo tshaj plaws ntawm kev zoo nkauj ntawm lub neej ua tau los ntawm kev tshawb fawb thiab thev naus laus zis. Cia peb tos ntsoov qhov kev ua tiav no pab txhawb kev noj qab haus huv ntawm ntau tus neeg.