03.uug 2023 | Ingqungquthela Yezokuthuthukiswa Kwe-BioPoprocess ye-Biopharmaceutical

2023 Ingqungquthela Yezokuthuthukiswa Kwe-BioProcess ye-BioPopropess ye-Bioprocess ye-Bioprocess,I-Radobio ibamba iqhaza njengomphakeli wesiko le-biopharmaceutical cell.

Ngokwesiko, i-laboology yelabhoraro bekulokhu kusebenza okuncane; Imikhumbi yesiko yezicubu ayikhudlwana kakhulu kunesandla sesandla somhloli, amavolumu alinganiswa "kuma-millienia," kanye nokuhlanzwa kwamaprotheni kubhekwa njengempumelelo uma kuthela ama-micrograms ambalwa. Ngomthelela okhulayo ocwaningweni lwe-Translational, i-Briology Yesayensi Yokwakheka, ososayensi abaningi baqala ukubheka "isithombe esikhulu". Noma ngabe bazama ukuhlanza amagremu ambalwa amaprotheni okuhlola ama-crystallization noma ahlole ukuthi kungenzeka yini ukuthi kusungulwe umkhiqizo wohlobo olusha olizweni olusha, laba abacwaningi basheshe bazithola becabanga ngezinkampani zamaseli amakhulu.

Ngenxa yempumelelo embonini ye-biotechnology, ukwanda okumi mpo kwesiko leseli sekuyindlela ye-trodden kahle. "Inkambu isivele iqhume imithungo njengoba imikhiqizo enkulu yemikhiqizo evelayo iyavela, isukela kuma-flashthicals ayi-100 ml accomical esikhushulwa kumaShekers kuya ku-1 000 l bioreactor amasiko, nezidakamizwa ezizokwazi ukukhiqizwa kumaseli amaningi.

I-Radobio inganikeza imikhiqizo enhle kakhulu ye-shaker yokumiswa kwamasiko amaseli, futhi kule nkomfa, kuboniswe umkhiqizo omusha we-Shaker CS345X, onobuhle obulandelayo:
❏ Amplitudes amaningi aguqukayo wezidingo ezahlukahlukene zesiko leseli.
▸ 12.5 / 25mm Amplitude ongaguquki, umuntu angahlangana kahle nokuhlolwa okuhlukile kwesiko, ngaphandle kwesidingo sokuthenga amadivaysi amaningi ezidingo ezahlukahlukene zokuhlola, ukonga abasebenzisi izindleko eziningi.
Ibanga le-❏ ebanzi isivinini, ijubane eliphansi elithambile nesivinini esiphakeme esisezingeni eliphakeme.
Ubuchwepheshe obuhlukile nobuciko obuqandayo buqhubeka buqhubeka ukwandisa ibanga lokulawula ngokushesha, okungabona uhla lokulawulwa kwejubane lwe-1 ~ 370rpm, ukuhlinzeka isiqinisekiso esisebenzayo sokuhlangabezana nezidingo ezahlukahlukene zokuhlola.
❏ Ukuvulwa komnyango okuphezulu kokonga isikhala futhi kunikeze ukufinyelela okulula kumasiko.
Ukuvulwa komnyango okushelelayo okushelelayo kugwema isikhala esihlalwe ukuvula komnyango wangaphandle, futhi sinikezela ngokufinyelela okulula kumasiko.
Umsebenzi wokulawula umswakama ongayikhetha ungalawula umswakama ufike ku-90% RH
▸ Imodyuli yokulawula yomswakama eyakhelwe ngaphakathi uRindo eyakhelwe iqinisekisa ukulawulwa komswakama okuqondile nokuthembekile ngokuqina kwe- ± 2% RH
❏ I-Magnetic Drayivu yokusebenza okubushelelezi, ukusetshenziswa kwamandla okuphansi, ukuvikelwa kwemvelo kanye nokusindisa kwamandla.
Akunasidingo samabhande, kunciphisa ubungozi bokungcoliswa ngenxa yokushisa kwangemuva kusuka ekushiseni kwebhande kumazinga okushisa okufakwa futhi ugqoke izinhlayiya.